Recombinant humaan Granzyme H-eiwit

GZMH also known as Granzyme H is essential for HBV eradication. The HBx protein (HBx), required for the replication of HBV, is cleaved at Met (79) by GZMH. GZMH inhibitor can abolish GZNH- and lymphokine-activated killer cell-mediated HBx degradation and HBV clearance. An HBx-deficient HBV is resistant to GzmH- and lymphokine-activated killer cell-mediated viral clearance. Recombinant human GZMH, fused to His-tag at N-terminus, was expressed in E. coli.

Granzyme H isoform 1, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.25 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

27.5 kDa (248aa)

Granzyme H, Granzyme H isoform 1, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2, ATGP3040-10 µg, ATGP3040-20 µg, ATGP3040-50 µg, ATGP3040-100 µg, ATGP3040-250 µg, ATGP3040-500 µg, ATGP3040-1 mg, ATGP3040-10, ATGP3040-20, ATGP3040-50, ATGP3040-100, ATGP3040-250, ATGP3040-500, ATGP3040-1

Ewen CL., et al. (2013) Mol. Immunol. 54 (3-4), 309-318 ; ; Wang L., et al. (2012) J. Immunol. 190 (3), 1319-1330 ;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Apoptosis

NP_219491

P20718

Human

MGSSHHHHHH SSGLVPRGSH MEIIGGHEAK PHSRPYMAFV QFLQEKSRKR CGGILVRKDF VLTAAHCQGS SINVTLGAHN IKEQERTQQF IPVKRPIPHP AYNPKNFSND IMLLQLERKA KWTTAVRPLR LPSSKAQVKP GQLCSVAGWG YVSMSTLATT LQEVLLTVQK DCQCERLFHG NYSRATEICV GDPKKTQTGF KGDSGGPLVC KDVAQGILSY GNKKGTPPGV YIKVSHFLPW IKRTMKRL