Recombinant humaan Granzyme H-eiwit

GZMH, as known as granzyme H isoform 1, is a member of the granzyme family of serine proteases found specifically in the granules of cytotoxic Tlymphocytes (CTL) and natural killer (NK) cells. The more abundant expression of this protein than granzyme B in NK cells suggests that granzyme H may complement the pro-apoptotic function of granzyme B in this cell type. Recombinant human GZMH, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Granzyme H isoform 1, GZMH, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

26.2 kDa (234aa)

Granzyme H, Granzyme H isoform 1, GZMH, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2, ATGP3370-10 µg, ATGP3370-20 µg, ATGP3370-50 µg, ATGP3370-100 µg, ATGP3370-250 µg, ATGP3370-500 µg, ATGP3370-1 mg, ATGP3370-10, ATGP3370-20, ATGP3370-50, ATGP3370-100, ATGP3370-250, ATGP3370-500, ATGP3370-1

Ronnberg E., et al. (2014) Int. Arch. Allergy Immunol. 165:68-74.; ; Tahbaz-Lahafi B., et al. (2014) Iran J Cancer Prev 7:48-52.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Apoptosis

NP_219491

P20718

Human

Glu19

EEIIGGHEAK PHSRPYMAFV QFLQEKSRKR CGGILVRKDF VLTAAHCQGS SINVTLGAHN IKEQERTQQF IPVKRPIPHP AYNPKNFSND IMLLQLERKA KWTTAVRPLR LPSSKAQVKP GQLCSVAGWG YVSMSTLATT LQEVLLTVQK DCQCERLFHG NYSRATEICV GDPKKTQTGF KGDSGGPLVC KDVAQGILSY GNKKGTPPGV YIKVSHFLPW IKRTMKRLHH HHHH