Recombinant humaan GSK-3 bèta-eiwit

GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Recombinant human GSK3B protein, was expressed in E. coli.

Glycogen synthase kinase 3 beta isoform 2, GSK-3 beta, Glycogen synthase kinase-3 beta

E.coli

Human

Non-Tagged

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

46 kDa (420aa)

GSK3 b, Glycogen synthase kinase 3 beta isoform 2, GSK-3 beta, Glycogen synthase kinase-3 beta, ATGP2503-10 µg, ATGP2503-20 µg, ATGP2503-50 µg, ATGP2503-100 µg, ATGP2503-250 µg, ATGP2503-500 µg, ATGP2503-1 mg, ATGP2503-10, ATGP2503-20, ATGP2503-50, ATGP2503-100, ATGP2503-250, ATGP2503-500, ATGP2503-1

Guo X, Ramirez A, et al. (2008) . Genes Dev. 22 (1) :106-20.; ; Espinosa L, Ingles-Esteve J, et al. (2003) . J Biol Chem. 278 (34) :32227-35.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Metabolism

NP_001139628

P49841

Human

MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST