Recombinant humaan HAND1-eiwit

HAND1 belongs to the basic helix-loop-helix family of transcription factors. This protein is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. Recombinant human HAND1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Heart and neural crest derivatives-expressed protein 1, bHLHa27, eHand, Hxt, Thing1

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

26 kDa (238aa)

HAND1, Heart and neural crest derivatives-expressed protein 1, bHLHa27, eHand, Hxt, Thing1, ATGP1739-10 µg, ATGP1739-20 µg, ATGP1739-50 µg, ATGP1739-100 µg, ATGP1739-250 µg, ATGP1739-500 µg, ATGP1739-1 mg, ATGP1739-10, ATGP1739-20, ATGP1739-50, ATGP1739-100, ATGP1739-250, ATGP1739-500, ATGP1739-1

Scott IC., et al. (2000) . Mol Cell Biol. 20 (2) :530-41.; ; Srivastava D. Trends Cardiovasc Med. 1999 Jan-Feb; ;9 (1-2) :11-8.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Development

NP_004812

O96004

Human

MGSSHHHHHH SSGLVPRGSH MGSMNLVGSY AHHHHHHHPH PAHPMLHEPF LFGPASRCHQ ERPYFQSWLL SPADAAPDFP AGGPPPAAAA AATAYGPDAR PGQSPGRLEA LGGRLGRRKG SGPKKERRRT ESINSAFAEL RECIPNVPAD TKLSKIKTLR LATSYIAYLM DVLAKDAQSG DPEAFKAELK KADGGRESKR KRELQQHEGF PPALGPVEKR IKGRTGWPQQ VWALELNQ