Recombinant humaan HES7-eiwit

HES7 is a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene. Recombinant human HES7 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Transcription factor HES-7, Hairy and enhancer of split 7; bHLHb37; SCDO4

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

27 kDa (253aa)

HES7, Transcription factor HES-7, Hairy and enhancer of split 7; bHLHb37; SCDO4, ATGP1838-10 µg, ATGP1838-20 µg, ATGP1838-50 µg, ATGP1838-100 µg, ATGP1838-250 µg, ATGP1838-500 µg, ATGP1838-1 mg, ATGP1838-10, ATGP1838-20, ATGP1838-50, ATGP1838-100, ATGP1838-250, ATGP1838-500, ATGP1838-1

Sparrow DB, et al. (2008) . Hum Mol Genet. 1; ;17 (23) :3761-6.; ; Sillence D, et al. (2010) . Eur J Hum Genet. 18 (6) :674-9.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Ubiquitination

NP_001159439

Q9BYE0

Human

MVTRDRA ENRDGPKMLK PLVEKRRRDR INRSLEELRL LLLERTRDQN LRNPKLEKAE ILEFAVGYLR ERSRVEPPAA AAPGVPRSPV QDAEALASCY LSGFRECLLR LAAFAHDASP AARAQLFSAL HGYLRPKPPR PKPVDPRPPA PRPSLDPAAP ALGPALHQRP PVHQGHPSPR CAWSPSLCSP RAGDSGAPAP LTGLLPPPPP PHRQDGAPKA PLPPPPAFWR PWP