Recombinant humaan HGF-eiwit

Hepatocyte growth factor (HGF) regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Recombinant human HGF protein was expressed in E. coli.

Hepatocyte growth factor isoform 1 preproprotein, DFNB39, F-TCF, HGFB, HPTA, SF

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 80% by SDS-PAGE

29.8 kDa (255aa)

HGF, Hepatocyte growth factor isoform 1 preproprotein, DFNB39, F-TCF, HGFB, HPTA, SF, ATGP2718-10 µg, ATGP2718-20 µg, ATGP2718-50 µg, ATGP2718-100 µg, ATGP2718-250 µg, ATGP2718-500 µg, ATGP2718-1 mg, ATGP2718-10, ATGP2718-20, ATGP2718-50, ATGP2718-100, ATGP2718-250, ATGP2718-500, ATGP2718-1

Wu X, Chen X, et al. (2013) . Cancer Lett. 10; ;335 (1) :128-35.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Hormones & Cytokines

NP_001010933

P14210

Human

MQRKRRNTIH EFKKSAKTTL IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SYRGKDLQEN YCRNPRGEEG GPWCFTSNPE VRYEVCDIPQ CSEVECMTCN GESYRGLMDH TESGKICQRW DHQTPHRHKF LPERYPDKGF DDNYCRNPDG QPRPWCYTLD PHTRWEYCAI KTCET