Recombinant humaan HLA-DOA-eiwit

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. Recombinant human HLA-DAO protein, fused to His-tag at N-terminus, was expressed in E. coli.

HLA class II histocompatibility antigen DO alpha chain, HLA class II histocompatibility antigen, DO alpha chain, HLA-DNA, HLA-DZA, HLADZ

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

24.1 kDa (215aa)

HLA-DOA, HLA class II histocompatibility antigen DO alpha chain, HLA class II histocompatibility antigen, DO alpha chain, HLA-DNA, HLA-DZA, HLADZ, ATGP2186-10 µg, ATGP2186-20 µg, ATGP2186-50 µg, ATGP2186-100 µg, ATGP2186-250 µg, ATGP2186-500 µg, ATGP2186-1 mg, ATGP2186-10, ATGP2186-20, ATGP2186-50, ATGP2186-100, ATGP2186-250, ATGP2186-500, ATGP2186-1

Yoon, T., et al. (2012) Proc. Natl. Acad. Sci. u.S.A. 109 (28), 11276-11281; ; Gieger, C., et al. (2012) Nature 480 (7376), 201-208

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol

Immunology

NP_002110

P06340

Human

TKADHMG SYGPAFYQSY GASGQFTHEF DEEQLFSVDL KKSEAVWRLP EFGDFARFDP QGGLAGIAAI KAHLDILVER SNRSRAINVP PRVTVLPKSR VELGQPNILI CIVDNIFPPV INITWLRNGQ TVTEGVAQTS FYSQPDHLFR KFHYLPFVPS AEDVYDCQVE HWGLDAPLLR HWELQVPIPP PDAME