Recombinant humaan HLA-DRB1-eiwit

HLA-DRB1, also known as major histocompatibility complex, class II, DR beta 1 precursor, belongs to the human leukocyte antigen (HLA) class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins to T helper cells. It helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. It is associated with an increased incidence of rheumatoid arthritis. Recombinant human HLA-DRB1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Major histocompatibility complex, class II, DR beta 1, HLA-DRB1, DRB1, HLA-DR1B, HLA-DRB, SS1

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

24 kDa (207aa)

HLA-DRB1, Major histocompatibility complex, class II, DR beta 1, HLA-DRB1, DRB1, HLA-DR1B, HLA-DRB, SS1, ATGP3818-10 µg, ATGP3818-20 µg, ATGP3818-50 µg, ATGP3818-100 µg, ATGP3818-250 µg, ATGP3818-500 µg, ATGP3818-1 mg, ATGP3818-10, ATGP3818-20, ATGP3818-50, ATGP3818-100, ATGP3818-250, ATGP3818-500, ATGP3818-1

De Silvestri A., et al. (2017) Autoimmun Rev. 16:1230-1236.; ; Riberdy JM., et al. (1992) Nature. 360:474-477.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol

Immunology

NP_002115

Q29974

Human

Ala

ADPGDTRPRF LWQPKRECHF FNGTERVRFL DRYFYNQEES VRFDSDVGEF RAVTELGRPD AEYWNSQKDI LEQARAAVDT YCRHNYGVVE SFTVQRRVQP KVTVYPSKTQ PLQHHNLLVC SVSGFYPGSI EVRWFLNGQE EKAGMVSTGL IQNGDWTFQT LVMLETVPRS GEVYTCQVEH PSVTSPLTVE WRARSESAQS KHHHHHH