Recombinant humaan HOMER1-eiwit

Homer 1 (Homer protein homolog 1) belongs to Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The Homer 1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs) . Recombinant Homer 1 protein was expressed in E. coli and purified by using conventional chromatography techniques.

HOMER, Homer protein homolog 1, HOMER1, HOMER1A, HOMER1B, HOMER1C, Neuronal immediate early gene, SYN47, Ves 1

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

44.5 kDa (391aa) confirmed by MALDI-TOF

HOMER, HOMER 1, HOMER 1A, HOMER 1B, HOMER 1C, Homer protein homolog 1, Homer protein homolog1, HOMER1, HOMER1A, HOMER1B, HOMER1C, Neuronal immediate early gene, Neuronal immediate early gene 1, SYN 47, SYN47, Ves 1, Ves1, ATGP0313-10 µg, ATGP0313-20 µg, ATGP0313-50 µg, ATGP0313-100 µg, ATGP0313-250 µg, ATGP0313-500 µg, ATGP0313-1 mg, ATGP0313-010, ATGP0313-020, ATGP0313-050, ATGP0313-100, ATGP0313-250, ATGP0313-500, ATGP0313-01M

Szumlinski KK., et al. (2008) Biochem Pharmacol. 75 (1) :112-133.; ; Roche KW., et al. (1999) J Biol Chem. 274 (36) :25953-7.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 30% glycerol, and 1mM DTT

Signal Transduction

NP_004263

Q86YM7

Human

HMGE QPIFSTRAHV FQIDPNTKKN WVPTSKHAVT VSYFYDSTRN VYRIISLDGS KAIINSTITP NMTFTKTSQK FGQWADSRAN TVYGLGFSSE HHLSKFAEKF QEFKEAARLA KEKSQEKMEL TSTPSQESAG GDLQSPLTPE SINGTDDERT PDVTQNSEPR AEPTQNALPF SHSSAISKHW EAELATLKGN NAKLTAALLE STANVKQWKQ QLAAYQEEAE RLHKRVTELE CVSSQANAVH THKTELNQTI QELEETLKLK EEEIERLKQE IDNARELQEQ RDSLTQKLQE VEIRNKDLEG QLSDLEQRLE KSQNEQEAFR NNLKTLLEIL DGKIFELTEL RDNLAKLLEC S