Recombinant humaan ICAT/CTNNBIP1-eiwit

CTNNBIP1 binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. This protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. Recombinant human CTNNBIP1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography

Beta catenin interacting protein 1, Inhibitor of beta-catenin and Tcf-4

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by BCA assay)

> 90% by SDS-PAGE

11.3 kDa (101a) confirmed by MALDI-TOF

Beta catenin interacting protein 1, Beta catenin interacting protein ICAT, Beta catenin interacting protein1, Beta-catenin-interacting protein 1, Catenin beta interacting protein 1, CTNNBIP 1, CTNNBIP1, ICAT, Inhibitor of beta catenin and Tcf 4, Inhibitor of beta-catenin and Tcf-4, MGC15093, ATGP0601-10 µg, ATGP0601-20 µg, ATGP0601-50 µg, ATGP0601-100 µg, ATGP0601-250 µg, ATGP0601-500 µg, ATGP0601-1 mg, ATGP0601-010, ATGP0601-020, ATGP0601-050, ATGP0601-100, ATGP0601-250, ATGP0601-500, ATGP0601-01M

Tago K., et al. (2000) Genes Dev. 14 (14) : 1741-9.; ; Daniels D.L., et al. (2002) Mol Cell 10:573-584;

Bertoldo D, et al. Phage Selection of Peptide Macrocycles against β-Catenin To Interfere with Wnt Signaling. (ChemMedChem. 2016) {https://pubmed.ncbi.nlm.nih.gov/26812578/}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 100 mM NaCl

Signal Transduction

NP_064633

Q9NSA3

Human

MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q