Recombinant humaan IFN-alfa/beta R1/IFNAR1-eiwit

IFN-alpha/beta R1, also known as interferon alpha/beta receptor 1 (IFNAR1), is a member of the class II cytokine receptor family of proteins that form heterodimeric receptor complexes. These receptors are shared and served multiple functions. IFNAR1 and IFNBR1, in association with IFNAR2 and IFNBR2, is required for propagating anti-microbial signal transduction triggered by the type 1 interferons such as IFN-alpha and IFN-beta. Also, binding and activation of it stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Recombinant Human IFN-alpha/beta R1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

IFN-alpha/beta R1, IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

47.9 kDa (415aa)

IFN-a, b R1, ATGP3894-10 µg, ATGP3894-20 µg, ATGP3894-50 µg, ATGP3894-100 µg, ATGP3894-250 µg, ATGP3894-500 µg, ATGP3894-1 mg, ATGP3894-10, ATGP3894-20, ATGP3894-50, ATGP3894-100, ATGP3894-250, ATGP3894-500, ATGP3894-1, ATGP3894-10 µg, ATGP3894-20 µg, ATGP3894-50 µg, ATGP3894-100 µg, ATGP3894-250 µg, ATGP3894-500 µg, ATGP3894-1 mg, ATGP3894-10, ATGP3894-20, ATGP3894-50, ATGP3894-100, ATGP3894-250, ATGP3894-500, ATGP3894-1

Richter MF., et al, (1998) J Biol Chem. 273:24723-24729.; ; Claudinon J., et al, (2009) J. Biol. Chem. 284:24328-24340.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Hormones & Cytokines

NP_000620

P17181

Human

Lys28