Recombinant humaan IFN-alfa/beta R2/IFNAR2-eiwit

IFN-alpha/beta R2, also known as IFNAR2, is a member of the class II cytokine receptor family. This protein is the principal ligand binding subunit of the receptor. Ligand bindnig is stabilized by the subsequent association with IFNAR1 and forms the signaling compelx recptor. It also plays the role in STAT1, STAT2, and STAT3 activation. Recombinant human IFN-alpha/beta R2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Human IFN-alpha 2 (CAT# IFN0502) is coated at 10 µg/mL (100 ul/well) can bind Human IFN-alpha/beta R2 in the presence of Human IFN-alpha/beta R1 (CAT# ATGP3894) . The ED50 range ≤ 500 ng/mL.

Interferon alpha/beta receptor 2, IFNAR2, IFN-alpha binding protein, Interferon alpha binding protein, Type I interferon receptor 2, interferon alpha/beta receptor 2 isoform a, IFN-R-2, IFNABR, IFNARB, IFN-alpha-REC, IFN-R, IMD45

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE, Bioactivity

0.25 mg/mL (determined by Absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

Measured by its binding ability in a functional ELISA with Human IFN-alpha 2 (CAT# IFN0502) in the presence of Human IFN-alpha/beta R1 (CAT# ATGP3894) . The ED50 range ≤ 500 ng/mL.

51.7kDa (456aa)

, ATGP3952-10 µg, ATGP3952-20 µg, ATGP3952-50 µg, ATGP3952-100 µg, ATGP3952-250 µg, ATGP3952-500 µg, ATGP3952-1 mg, ATGP3952-10, ATGP3952-20, ATGP3952-50, ATGP3952-100, ATGP3952-250, ATGP3952-500, ATGP3952-1

Grazziola C, et al, (2005) Int J Oncol 26:129-140.; ; Ortiz A, et al, (2019) Cancer Cell 35:33-45.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology, Hormones & Cytokines

NP_997468

P48551

Human

Ile