Recombinant humaan IGFBP-rp1/IGFBP-7 eiwit

IGFBP7 is a member of the insulin-like growth factor (IGF) -binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm Recombinant human IGFBP7 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Insulin-like growth factor-binding protein 7 isoform 1 precursor, insulin-like growth factor-binding protein 7 isoform 1 precursor, AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF

E.coli

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

28.8 kDa (279aa) confirmed by MALDI-TOF

IGFBP-rp1, IGFBP7, insulin-like growth factor-binding protein 7 isoform 1 precursor, insulin-like growth factor-binding protein 7 isoform 1 precursor, AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF, ATGP2483-10 µg, ATGP2483-20 µg, ATGP2483-50 µg, ATGP2483-100 µg, ATGP2483-250 µg, ATGP2483-500 µg, ATGP2483-1 mg, ATGP2483-10, ATGP2483-20, ATGP2483-50, ATGP2483-100, ATGP2483-250, ATGP2483-500, ATGP2483-1

Akaogi K., et al (1994) . Biochem. Biophys. Res. Commun. 198:1046-1053; ; Oh Y., et al (1996) . J. Biol. Chem. 271:30322-30325;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT, 1mM EDTA

Cancer

NP_001544

Q16270

Human

MGSSHHHHHH SSGLVPRGSH MGSSSSDTCG PCEPASCPPL PPLGCLLGET RDACGCCPMC ARGEGEPCGG GGAGRGYCAP GMECVKSRKR RKGKAGAAAG GPGVSGVCVC KSRYPVCGSD GTTYPSGCQL RAASQRAESR GEKAITQVSK GTCEQGPSIV TPPKDIWNVT GAQVYLSCEV IGIPTPVLIW NKVKRGHYGV QRTELLPGDR DNLAIQTRGG PEKHEVTGWV LVSPLSKEDA GEYECHASNS QGQASASAKI TVVDALHEIP VKKGEGAEL