Recombinant humaan IL-18BP-eiwit

IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Recombinant human IL18BP protein, fused to His-tag at N-terminus, was expressed in E. coli.

Interleukin-18-binding protein, IL18BPa, Interleukin-18-binding protein isoform, IL18BP, Tadekinig-alfa

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

20 kDa (187aa)

Interleukin-18 binding protein, Interleukin 18 binding protein, Interleukin-18-binding protein, IL18BPa, Interleukin 18 binding protein isoform, Interleukin-18-binding protein isoform, Interleukin18 binding protein isoform, IL18BP, Tadekinig-alfa, Tadekinig alfa, ATGP1940-10 µg, ATGP1940-20 µg, ATGP1940-50 µg, ATGP1940-100 µg, ATGP1940-250 µg, ATGP1940-500 µg, ATGP1940-1 mg, ATGP1940-010, ATGP1940-020, ATGP1940-050, ATGP1940-100, ATGP1940-250, ATGP1940-500, ATGP1940-01M

Shimizu, C., et al. (2012) Mod Rheumatol 22 (1), 73-79; ; Fujita, T., et al. (2011) Diabetes Res. Clin. Pract. 92 (3), E66-E69

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Immunology

NP_001138529

O95998

Human

MGSSHHHHHH SSGLVPRGSH MGSTPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVP LNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTN FSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSH SSPQQQG