Recombinant humaan IL-4R alfa/IL4R eiwit

IL4R, also known as interleukin 4 receptor subunit alpha isoform, is a pleiotropic cytokine produced by T lymphocytes. It plays an important role in immune responsiveness by regulating proliferation and differentiation of a variety of lymphoid and myeloid cells via binding to high affinity receptors. It markedly inhibits IL-1 production by highly purified normal human monocytes. It has been demonstrated to affect the growth of different human malignancies including pancreatic cancer cells. It plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. Recombinant human IL4R, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Interleukin 4 receptor subunit alpha isoform, IL4R, CD124, IL-4RA, IL4RA, IL-4 receptor subunit alpha; IL-4R subunit alpha

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by BCA assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

24.7 kDa (215aa)

IL4 R a, Interleukin 4 receptor subunit alpha isoform, IL4R, CD124, IL-4RA, IL4RA, ATGP3710-10 µg, ATGP3710-20 µg, ATGP3710-50 µg, ATGP3710-100 µg, ATGP3710-250 µg, ATGP3710-500 µg, ATGP3710-1 mg, ATGP3710-10, ATGP3710-20, ATGP3710-50, ATGP3710-100, ATGP3710-250, ATGP3710-500, ATGP3710-1

Traub B., et al. (2017) Int J Mol Sci. 18.; ; Idzerda RL., et al. (1990) J Exp Med. 171:861-873.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4)

Immunology

NP_000409

P24394

Human

Met26