Recombinant humaan IMPA2-eiwit

IMPA2 belongs to the inositol monophosphatase family. This protein can use myo-inositol monophosphates, scylloinositol 1, 4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 has been implicated as the pharmacological target for lithium Li (+) action in brain. IMPA2 is thought to play a role in schizophrenia and bipolar disorder. Recombinant human IMPA2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Inositol monophosphatase 2, Inositol (myo) -1 (or 4) -monophosphatase 2

E.coli

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

33.5 kDa (308aa) confirmed by MALDI-TOF

IMPA2, Inositol monophosphatase 2, Inositol (myo) -1 (or 4) -monophosphatase 2, ATGP0913-10 µg, ATGP0913-20 µg, ATGP0913-50 µg, ATGP0913-100 µg, ATGP0913-250 µg, ATGP0913-500 µg, ATGP0913-1 mg, ATGP0913-10, ATGP0913-20, ATGP0913-50, ATGP0913-100, ATGP0913-250, ATGP0913-500, ATGP0913-1

Sjoholt G., et al. (2000) Mol Psychiatry. 5 (2) :172-80. ; ; Yoshikawa T., et al. (1997) Mol Psychiatry. 2 (5) :393-7.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT

Metabolism

NP_055029

O14732

Human

MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK