Recombinant humaan IMPAD1-eiwit

Inositol monophosphatase 3, also known as IMPAD1, is a member of the inositol monophosphatase family. IMPAD1 is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP) . Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. Recombinant human IMPAD1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Inositol monophosphatase 3, GPAPP, IMP 3, IMP-3, IMPA3

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

37.6 kDa (349aa)

IMPAD1, Inositol monophosphatase 3, GPAPP, IMP 3, IMP-3, IMPA3, ATGP1889-10 µg, ATGP1889-20 µg, ATGP1889-50 µg, ATGP1889-100 µg, ATGP1889-250 µg, ATGP1889-500 µg, ATGP1889-1 mg, ATGP1889-10, ATGP1889-20, ATGP1889-50, ATGP1889-100, ATGP1889-250, ATGP1889-500, ATGP1889-1

Vissers L E., et al. (2011) Am J Hum Genet. 88 (5) :608-15.; ; Kalujnaia S., et al. (2010) FASEB J. 24 (10) :3981-91.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% glycerol

Metabolism

NP_060283

Q9NX62

Human

MGSSHHHHHH SSGLVPRGSH MGSGRFSLFG LGGEPGGGAA GPAAAADGGT VDLREMLAVS VLAAVRGGDE VRRVRESNVL HEKSKGKTRE GAEDKMTSGD VLSNRKMFYL LKTAFPSVQI NTEEHVDAAD QEVILWDHKI PEDILKEVTT PKEVPAESVT VWIDPLDATQ EYTEDLRKYV TTMVCVAVNG KPMLGVIHKP FSEYTAWAMV DGGSNVKARS SYNEKTPRIV VSRSHSGMVK QVALQTFGNQ TTIIPAGGAG YKVLALLDVP DKSQEKADLY IHVTYIKKWD ICAGNAILKA LGGHMTTLSG EEISYTGSDG IEGGLLASIR MNHQALVRKL PDLEKTGHK