Recombinant humaan Integrine beta 1/CD29 eiwit

ITGB1, also known as integrin beta-1 isoform 1A, is the only alpha 1 integrin family adhesion receptor, one of twelve integrins that share the beta 1 subunit, and one of four collagen binding integrins. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This protein is reported to down-regulate EGF-R signaling, increase expression of caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, control MMP collagenase and gelatinase activity, and mediate the renal basement membrane disorder Alport syndrome. Recombinant human ITGB1 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

CD29, Fibronectin receptor subunit beta, FNRB, Glycoprotein Iia, GPIIA, Integrin beta-1 isoform 1A, ITGB1, MDF2, MSK12, VLA-4 subunit beta, VLAB, VLA-BETA

Baculovirus

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

79.4 kDa (716aa)

VLA-BETA, VLAB, VLA-4 subunit beta, NRK2, Nicotinamide riboside kinase 2, MSK12, MIBP, MDF2, ITGB1, Interleukin-6, Interleukin6, Interleukin 6, Interferon beta 2, Integrin beta-1 isoform 1A, Integrin beta 1, Integrin b1, Il-6, IL6, IFNB2, IFNB 2, IFN B2, IFN B 2, I L6, HSF, HGF, GPIIA, Glycoprotein Iia, FNRB, Fibronectin receptor subunit beta, CD29, BSF2, BSF 2, ATGP3549-10 µg, ATGP3549-20 µg, ATGP3549-50 µg, ATGP3549-100 µg, ATGP3549-250 µg, ATGP3549-500 µg, ATGP3549-1 mg, ATGP3549-010, ATGP3549-020, ATGP3549-050, ATGP3549-100, ATGP3549-250, ATGP3549-500, ATGP3549-01M

Wang XM., et al. (2013) PLoS One. 8: e55714.; ; Minchenko OH., et al. (2014) Ukr Biochem J. 86:79-89.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_002202.2

P05556

Human

Gln21