Recombinant humaan Integrine beta 2/CD18 eiwit

ITGB2, also known as integrin beta-2, is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It may belong to an extended family of cell surface molecules including the fibronectin binding protein. Also It is a complement receptor type 3 (CR3) . It triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Recombinant human ITGB2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

ITGB2, Cell surface adhesion glycoproteins LFA-1, CR3, p150,95 subunit beta, Complement receptor C3 subunit beta, MFI7, MAC-1

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 85% by SDS-PAGE

75.9 kDa (686aa)

Integrin a L b2, Integrin beta-2, ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, ATGP3351-10 µg, ATGP3351-20 µg, ATGP3351-50 µg, ATGP3351-100 µg, ATGP3351-250 µg, ATGP3351-500 µg, ATGP3351-1 mg, ATGP3351-10, ATGP3351-20, ATGP3351-50, ATGP3351-100, ATGP3351-250, ATGP3351-500, ATGP3351-1

Law SK., et al. (1987) EMBO J. 6:915-919.; ; Xu J., et al. (2008) Nat Immunol. 9:880-886.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_000202.2

P05107

Human

Gln23