Recombinant humaan Integrine beta 4/CD104 eiwit

ITGB4, also known as integrin beta-4 isoform 1, is a member of the Integrin beta family. It forms noncovalent heterodimers with Integrin alpha 6 and participates in the formation of epithelial hemidesmosomes. This protein plays a critical structural role in the hemidesmosome of epithelial cells and is required for the regulation of keratinocyte polarity and motility. The heterodimer of them binds to NRG1 and this binding is essential for NRG1-ERBB signaling and binds to IGF1 and this binding is essential for IGF1 signaling. It tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Recombinant human ITGB4 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Integrin beta-4 isoform 1, ITGB4, CD104, GP150

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

77.5 kDa (691aa)

Integrin b4, Integrin beta-4 isoform 1, ITGB4, CD104, GP150, ATGP3753-10 µg, ATGP3753-20 µg, ATGP3753-50 µg, ATGP3753-100 µg, ATGP3753-250 µg, ATGP3753-500 µg, ATGP3753-1 mg, ATGP3753-10, ATGP3753-20, ATGP3753-50, ATGP3753-100, ATGP3753-250, ATGP3753-500, ATGP3753-1

An XZ., et al, (2016) Oncotarget. 7:24719-24733.; ; Li XL., et al, (2017) Sci Rep. 7:40464.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_000204.3

P16144

Human

Asn28