Recombinant humaan IRMG-eiwit

Immunity-related GTPase family M protein, also known as IRGM, is required for clearance of acute protozoan and bacterial infections. This protein functions in innate immune response probably through regulation of autophagy. It may regulate proinflammatory cytokine production and prevent endotoxemia upon infection and may also play a role in macrophages adhesion and motility. Recombinant human IRGM protein, fused to His-tag at N-terminus, was expressed in E. coli.

Immunity-related GTPase family M protein, IFI1, IRGM1, LRG-47, LRG47, MGC149263, MGC149264

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

20.1 kDa (180aa)

IRGM, Immunity-related GTPase family M protein, IFI1, IRGM1, LRG-47, LRG47, MGC149263, MGC149264, ATGP1833-10 µg, ATGP1833-20 µg, ATGP1833-50 µg, ATGP1833-100 µg, ATGP1833-250 µg, ATGP1833-500 µg, ATGP1833-1 mg, ATGP1833-10, ATGP1833-20, ATGP1833-50, ATGP1833-100, ATGP1833-250, ATGP1833-500, ATGP1833-1

Singh S.B., et al. (2006) Science. 313:1438-1441; ; Parkes M., et al. (2007) Nat. Genet. 39:830-832;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 10% glycerol

Immunology

NP_001139277

A1A4Y4

Human

KETLKIVSR TPVNITMAGD SGNGMSTFIS ALRNTGHEGK ASPPTELVKA TQRCASYFSS HFSNVVLWDL PGTGSATTTL ENYLMEMQFN RYDFIMVASA QFSMNHVMLA KTAEDMGKKF YIVWTKLDMD LSTGALPEVQ LLQIRENVLE NLQKERVCEY