Recombinant humaan ITGB3BP-eiwit

Cntromere protein R isoform 1, also known as ITGB3BP1, is a widely expressed protein that contains a DD1 or RepD1 domain and an LXXLL motif. Induced by estrogen, ITGB3BP1 is believed to function as a nuclear receptor coactivator. It also associates with the CENP-A-CAD complex which is involved in mitotic progression, the assembly of kinetochore proteins and chromosome segregation. It acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Recombinant human ITGB3BP1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Cntromere protein R isoform 1, CENP-R, CENPR, HSu37139, NRIF3, TAP20

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

27.1 kDa (239aa)

ITGB3BP, Cntromere protein R isoform 1, CENP-R, CENPR, HSu37139, NRIF3, TAP20, ATGP2058-10 µg, ATGP2058-20 µg, ATGP2058-50 µg, ATGP2058-100 µg, ATGP2058-250 µg, ATGP2058-500 µg, ATGP2058-1 mg, ATGP2058-10, ATGP2058-20, ATGP2058-50, ATGP2058-100, ATGP2058-250, ATGP2058-500, ATGP2058-1

Foltz D R., et al. (2006) Nat Cell Biol. 8:458-469.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Epigenomics (Transcription & Translation)

NP_001193668

Q13352

Human

MGSSHHHHHH SSGLVPRGSH MGSMPFAPVA QARVQWHDFR SLQHLLPAFK RFSCLSLGSS WDYSVKRSLK LDGLLEENSF DPSKITRKKS VITYSPTTGT CQMSLFASPT SSEEQKHRNG LSNEKRKKLN HPSLTESKES TTKDNDEFMM LLSKVEKLSE EIMEIMQNLS SIQALEGSRE LENLIGISCA SHFLKREMQK TKELMTKVNK QKLFEKSTGL PHKASRHLDS YEFLKAILN