Recombinant humaan Kallikreïne 15/KLK15-eiwit

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK15 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, it has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. KLK15 contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. Recombinant human KLK15 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Kallikrein-15, kallikrein related peptidase 15, ACO protease, HSRNASPH, prostinogen

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

28.2 kDa (258aa)

Prostinogen, KLK15, KLK 15, Kallikrein-related peptidase 15, Kallikrein-15 isoform 4 preproprotein, Kallikrein-15, Kallikrein15, Kallikrein 15, Kallikrein 15 isoform 4 preproprotein, Kallikrein related peptidase 15, HSRNASPH, ACO protease, ACO, ATGP2558-10 µg, ATGP2558-20 µg, ATGP2558-50 µg, ATGP2558-100 µg, ATGP2558-250 µg, ATGP2558-500 µg, ATGP2558-1 mg, ATGP2558-010, ATGP2558-020, ATGP2558-050, ATGP2558-100, ATGP2558-250, ATGP2558-500, ATGP2558-01M

Yousef GM, Scorilas A, et al. (2001) J Biol Chem 276 (1) : 53-61.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Cancer

NP_059979

Q9H2R5

Human

MGSSHHHHHH SSGLVPRGSH MGSLLEGDEC APHSQPWQVA LYERGRFNCG ASLISPHWVL SAAHCQSRFM RVRLGEHNLR KRDGPEQLRT TSRVIPHPRY EARSHRNDIM LLRLVQPARL NPQVRPAVLP TRCPHPGEAC VVSGWGLVSH NEPGTAGSPR SQVSLPDTLH CANISIISDT SCDKSYPGRL TNTMVCAGAE GRGAESCEGD SGGPLVCGGI LQGIVSWGDV PCDNTTKPGV YTKVCHYLEW IRETMKRN