Recombinant humaan Kallikreïne 7/KLK7-eiwit

KLK7, as known as kallikrein-7 isoform 2, is a secreted protein which belongs to the peptidase S1 family and kallikrein subfamily. Members of the kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK10), and breast cancer (KLK10, KLK13, LKL14) . This protein is expressed in the skin, a major physiological function of KLK7 is to regulate the desquamation process through proteolysis of the intercellular adhesive structure between corneocytes. Recombinant human KLK7, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Stratum corneum chymotryptic enzyme, Serine protease 6, SCCE, PRSS6, KLK7, Kallikrein-7 isoform 2, Kallikrein-7, Kallikrein related peptidase 7, HK7

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

20.9 kDa (190aa)

Stratum corneum chymotryptic enzyme, Serine protease 6, SCCE, PRSS6, KLK7, Kallikrein-7 isoform 2, Kallikrein-7, Kallikrein related peptidase 7, HK7, ATGP3371-10 µg, ATGP3371-20 µg, ATGP3371-50 µg, ATGP3371-100 µg, ATGP3371-250 µg, ATGP3371-500 µg, ATGP3371-1 mg, ATGP3371-010, ATGP3371-020, ATGP3371-050, ATGP3371-100, ATGP3371-250, ATGP3371-500, ATGP3371-01M

Yu Y., et al. (2015) J. Biol. Chem. 290:17762-17775.; ; Tamir A., et al. (2014) J. Ovarian. Res. 7:109-124.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_001193982

P49862

Human

Ala

ADPMNEYTVH LGSDTLGDRR AQRIKASKSF RHPGYSTQTH VNDLMLVKLN SQARLSSMVK KVRLPSRCEP PGTTCTVSGW GTTTSPDVTF PSDLMCVDVK LISPQDCTKV YKDLLENSML CAGIPDSKKN ACNGDSGGPL VCRGTLQGLV SWGTFPCGQP NDPGVYTQVC KFTKWINDTM KKHRHHHHHH