Recombinant humaan KCNIP3-eiwit

KCNIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins containing EF-hand-like domains. This protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Recombinant human KCNIP3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Calsenilin, Calsenilin, CSEN, DREAM, KCHIP3, MGC18289

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

31.4 kDa (276aa) confirmed by MALDI-TOF

KCNIP3, Calsenilin, Calsenilin, CSEN, DREAM, KCHIP3, MGC18289, ATGP0789-10 µg, ATGP0789-20 µg, ATGP0789-50 µg, ATGP0789-100 µg, ATGP0789-250 µg, ATGP0789-500 µg, ATGP0789-1 mg, ATGP0789-10, ATGP0789-20, ATGP0789-50, ATGP0789-100, ATGP0789-250, ATGP0789-500, ATGP0789-1

Buxbaum JD., et al. (1998) Nat Med. 4 (10) :1177-81.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

Neuroscience

NP_038462

Q9Y2W7

Human

MGSSHHHHHH SSGLVPRGSH MQPAKEVTKA SDGSLLGDLG HTPLSKKEGI KWQRPRLSRQ ALMRCCLVKW ILSSTAPQGS DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYAQ FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG YITKEEMLAI MKSIYDMMGR HTYPILREDA PAEHVERFFE KMDRNQDGVV TIEEFLEACQ KDENIMSSMQ LFENVI