Recombinant humaan KCTD11-eiwit

BTB/POZ domain-containing protein KCTD11, is a 232 amino acid regulator of neuronal differentiation that induces growth arrest, apoptosis and the expression of p27, a cyclin-dependent kinase inhibitor. Expressed at highest levels in cerebellum, KCTD11 functions as an antagonist of the Hedgehog pathway and activator of the caspase cascade. Recombinant human KCTD11 protein, fused to His-tag at N-terminus, was expressed in E. coli.

BTB/POZ domain-containing protein KCTD11, C17orf36, KCASH1, MGC129844, REN, REN/KCTD11

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

28 kDa (252aa)

KCTD11, BTB/POZ domain-containing protein KCTD11, C17orf36, KCASH1, MGC129844, REN, REN/KCTD11, ATGP1983-10 µg, ATGP1983-20 µg, ATGP1983-50 µg, ATGP1983-100 µg, ATGP1983-250 µg, ATGP1983-500 µg, ATGP1983-1 mg, ATGP1983-10, ATGP1983-20, ATGP1983-50, ATGP1983-100, ATGP1983-250, ATGP1983-500, ATGP1983-1

Gallo R., et al. (2002) J Cell Biol. 158:731-740.; ; Di Marcotullio L., et al. (2004) Proc Natl Acad Sci uSA. 101:10833-10838.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Signal Transduction

NP_001002914.1

Q693B1

Human

MLGAMFRAGT PMPPNLNSQG GGHYFIDRDG KAFRHILNFL RLGRLDLPRG YGETALLRAE ADFYQIRPLL DALRELEASQ GTPAPTAALL HADVDVSPRL VHFSARRGPH HYELSSVQVD TFRANLFCTD SECLGALRAR FGVASGDRAE GSPHFHLEWA PRPVELPEVE YGRLGLQPLW TGGPGERREV VGTPSFLEEV LRVALEHGFR LDSVFPDPED LLNSRSLRFV RH