Recombinant humaan KRT16-eiwit

KRT16 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. Recombinant human KRT16 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Keratin type I cytoskeletal 16, Keratin, type I cytoskeletal 16, CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

53.7 kDa (496aa)

KRT16, Keratin type I cytoskeletal 16, Keratin, type I cytoskeletal 16, CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, ATGP2599-10 µg, ATGP2599-20 µg, ATGP2599-50 µg, ATGP2599-100 µg, ATGP2599-250 µg, ATGP2599-500 µg, ATGP2599-1 mg, ATGP2599-10, ATGP2599-20, ATGP2599-50, ATGP2599-100, ATGP2599-250, ATGP2599-500, ATGP2599-1

Du ZF, Xu CM, Zhao Y, et al. (2012) . Eur J Dermatol. 22 (4) :476-80.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Signal Transduction

NP_005548

P08779

Human

MGSSHHHHHH SSGLVPRGSH MGSMTTCSRQ FTSSSSMKGS CGIGGGIGGG SSRISSVLAG GSCRAPSTYG GGLSVSSRFS SGGACGLGGG YGGGFSSSSS FGSGFGGGYG GGLGAGFGGG LGAGFGGGFA GGDGLLVGSE KVTMQNLNDR LASYLDKVRA LEEANADLEV KIRDWYQRQR PSEIKDYSPY FKTIEDLRNK IIAATIENAQ PILQIDNARL AADDFRTKYE HELALRQTVE ADVNGLRRVL DELTLARTDL EMQIEGLKEE LAYLRKNHEE EMLALRGQTG GDVNVEMDAA PGVDLSRILN EMRDQYEQMA EKNRRDAETW FLSKTEELNK EVASNSELVQ SSRSEVTELR RVLQGLEIEL QSQLSMKASL ENSLEETKGR YCMQLSQIQG LIGSVEEQLA QLRCEMEQQS QEYQILLDVK TRLEQEIATY RRLLEGEDAH LSSQQASGQS YSSREVFTSS SSSSSRQTRP ILKEQSSSSF SQGQSS