Recombinant humaan L1CAM-eiwit

L1CAM, also known as neural cell adhesion molecule L1 isoform 3, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. It is now recognized to play a key role in cell migration, adhesion, neurite outgrowth, myelination and neuronal differentiation Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recombinant human L1CAM, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Neural cell adhesion molecule L1 isoform 3, L1CAM, CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

123.6 kDa (1104aa)

L1CAM, Neural cell adhesion molecule L1 isoform 3, L1CAM, CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1, ATGP3618-10 µg, ATGP3618-20 µg, ATGP3618-50 µg, ATGP3618-100 µg, ATGP3618-250 µg, ATGP3618-500 µg, ATGP3618-1 mg, ATGP3618-10, ATGP3618-20, ATGP3618-50, ATGP3618-100, ATGP3618-250, ATGP3618-500, ATGP3618-1

Maness, P.F., et al. (2007) Nat. Neurosci. 10:19-26.; ; Gavert, N., et al. (2008) Expert Opin Biol Ther. 8 (11) :1749-57.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

NP_001137435

P32004

Human

Ile20