Recombinant humaan LINGO-1-eiwit

Lingo1 also known as Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein1. LINGO-1 is primarily expressed in neuronal tissue, and most abundantly in cortex. It has been implicated in the inhibition of axon regeneration through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit) . The inhibitory action is achieved through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system. LINGO-1 also inhibits oligodendrocyte precursor differentiation and myelination, by a mechanism that also involves activation of RhoA, but which apparently does not require 75 or NgR1. Recombinant human LINGO1 protein, was expressed in E. coli

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein1, LERN1, LRRN6A, uNQ201

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

15.1 kDa (133aa)

LINGO1, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein1, LERN1, LRRN6A, uNQ201, ATGP3011-10 µg, ATGP3011-20 µg, ATGP3011-50 µg, ATGP3011-100 µg, ATGP3011-250 µg, ATGP3011-500 µg, ATGP3011-1 mg, ATGP3011-10, ATGP3011-20, ATGP3011-50, ATGP3011-100, ATGP3011-250, ATGP3011-500, ATGP3011-1

Mi S., et al (2004) . Nat. Neurosci. 7:221-228.; ; Mi S., et al (2005) . Nat. Neurosci. 8:745-751.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Neuroscience

NP_116197

Q96FE5

Human

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSLKVL EISHWPYLDT MTPNCLYGLN LTSLSITHCN LTAVPYLAVR HLVYLRFLNL SYNPISTIEG SMLHELLRLQ EIQLVGGQLA VVEPYAFRGL NYL