Recombinant humaan Lumican eiwit

LuM is a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. Recombinant human LuM protein, fused to His-tag at N-terminus, was expressed in E. coli.

Lumican precursor, Lumican precursor, LDC, SLRR2D

E.coli

Human

His-Tag

SDS-PAGE, Denatured

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

39 kDa (343aa)

Lumican, Lumican precursor, Lumican precursor, LDC, SLRR2D, ATGP2491-10 µg, ATGP2491-20 µg, ATGP2491-50 µg, ATGP2491-100 µg, ATGP2491-250 µg, ATGP2491-500 µg, ATGP2491-1 mg, ATGP2491-10, ATGP2491-20, ATGP2491-50, ATGP2491-100, ATGP2491-250, ATGP2491-500, ATGP2491-1

Chakravarti S, Stallings RL, et al. (1995) . Genomics. 27 (3) :481-8.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Cancer

NP_002336

P51884

Human

QYYDYDF PLSIYGQSSP NCAPECNCPE SYPSAMYCDE LKLKSVPMVP PGIKYLYLRN NQIDHIDEKA FENVTDLQWL ILDHNLLENS KIKGRVFSKL KQLKKLHINH NNLTESVGPL PKSLEDLQLT HNKITKLGSF EGLVNLTFIH LQHNRLKEDA VSAAFKGLKS LEYLDLSFNQ IARLPSGLPV SLLTLYLDNN KISNIPDEYF KRFNALQYLR LSHNELADSG IPGNSFNVSS LVELDLSYNK LKNIPTVNEN LENYYLEVNQ LEKFDIKSFC KILGPLSYSK IKHLRLDGNR ISETSLPPDM YECLRVANEV TLN