Recombinant humaan LZTFL1-eiwit

LZTFL1 is a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. LZTFL1 may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Recombinant human LZTFL1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Leucine zipper transcription factor-like protein 1, Leucine zipper transcription factor-like protein 1, BBS17

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

37 kDa (322aa) confirmed by MALDI-TOF

LZTFL1, Leucine zipper transcription factor-like protein 1, Leucine zipper transcription factor-like protein 1, BBS17, ATGP2929-10 µg, ATGP2929-20 µg, ATGP2929-50 µg, ATGP2929-100 µg, ATGP2929-250 µg, ATGP2929-500 µg, ATGP2929-1 mg, ATGP2929-10, ATGP2929-20, ATGP2929-50, ATGP2929-100, ATGP2929-250, ATGP2929-500, ATGP2929-1

Wei Q., et al. (2010) Cancer Res. 70 (7), 2942-2950

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT

Epigenetics and Nuclear Signaling

NP_065080

Q9NQ48

Human

MAELGLN EHHQNEVINY MRFARSKRGL RLKTVDSCFQ DLKESRLVED TFTIDEVSEV LNGLQAVVHS EVESELINTA YTNVLLLRQL FAQAEKWYLK LQTDISELEN RELLEQVAEF EKAEITSSNK KPILDVTKPK LAPLNEGGTA ELLNKEILRL QEENEKLKSR LKTIEIQATN ALDEKSKLEK ALQDLQLDQG NQKDFIKAQD LSNLENTVAA LKSEFQKTLN DKTENQKSLE ENLATAKHDL LRVQEQLHMA EKELEKKFQQ TAAYRNMKEI LTKKNDQIKD LRKRLAQYEP ED