Recombinant humaan MAP1/MOAP1-eiwit

Modulator of apoptosis 1, also known as MOAP1, belongs to the PNMA family and contains one BH3-like domain and one RASSF1-binding domain. It is required for death receptor-dependent apoptosis. MOAP1 homodimerizes and associates with the proapoptotic Bax and the prosurvival Bcl-2 and Bcl-X (L) of the Bcl-2 family in vitro and in vivo in mammalian cells. These data suggest that MOAP1 mediates apoptosis through a mechanism that involves binding to Bax. Recombinant human MOAP1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Modulator of apoptosis 1, MAP-1, PNMA4, Paraneoplastic antigen Ma4

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

41.9 kDa (374aa)

MOAP1, Modulator of apoptosis 1, MAP-1, PNMA4, ATGP2404-10 µg, ATGP2404-20 µg, ATGP2404-50 µg, ATGP2404-100 µg, ATGP2404-250 µg, ATGP2404-500 µg, ATGP2404-1 mg, ATGP2404-10, ATGP2404-20, ATGP2404-50, ATGP2404-100, ATGP2404-250, ATGP2404-500, ATGP2404-1

Baksh S., et al. (2005) Mol Cell. 18:637-650.; ; Tan K O., et al. (2001) J Biol Chem. 276:2802-2807.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Apoptosis

NP_071434

Q96BY2

Human

MGSSHHHHHH SSGLVPRGSH MGSMTLRLLE DWCRGMDMNP RKALLIAGIS QSCSVAEIEE ALQAGLAPLG EYRLLGRMFR RDENRKVALV GLTAETSHAL VPKEIPGKGG IWRVIFKPPD PDNTFLSRLN EFLAGEGMTV GELSRALGHE NGSLDPEQGM IPEMWAPMLA QALEALQPAL QCLKYKKLRV FSGRESPEPG EEEFGRWMFH TTQMIKAWQV PDVEKRRRLL ESLRGPALDV IRVLKINNPL ITVDECLQAL EEVFGVTDNP RELQVKYLTT YQKDEEKLSA YVLRLEPLLQ KLVQRGAIER DAVNQARLDQ VIAGAVHKTI RRELNLPEDG PAPGFLQLLV LIKDYEAAEE EEALLQAILE GNFT