Recombinant humaan MBL-eiwit

MBL2, also known as mannose-binding protein C, belongs to the class of collectins in the C-type lectin superfamily. It is a lectin that is instrumental in innate immunity via the lectin pathway. It recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa and fungi. It It binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes. This protein has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Also, mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection. Recombinant human MBL2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Mannose binding lectin 2, MBL, Collectin 1, Mannose-binding protein, COLEC1, MBP-C, MBP1, MBP

Baculovirus

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

25.1 kDa (237aa)

MBL2, Mannose-binding protein C, MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD, ATGP3749-10 µg, ATGP3749-20 µg, ATGP3749-50 µg, ATGP3749-100 µg, ATGP3749-250 µg, ATGP3749-500 µg, ATGP3749-1 mg, ATGP3749-10, ATGP3749-20, ATGP3749-50, ATGP3749-100, ATGP3749-250, ATGP3749-500, ATGP3749-1

Tomaiuolo R., et al. (2012) Aging Cell. 11:394-400.; ; Stuart LM., et al. (2005) J Immunol. 174:3220-3226.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_000233.1

P11226

Human

Ala

ETVTCED AQKTCPAVIA CSSPGINGFP GKDGRDGTKG EKGEPGQGLR GLQGPPGKLG PPGNPGPSGS PGPKGQKGDP GKSPDGDSSL AASERKALQT EMARIKKWLT FSLGKQVGNK FFLTNGEIMT FEKVKALCVK FQASVATPRN AAENGAIQNL IKEEAFLGIT DEKTEGQFVD LTGNRLTYTN WNEGEPNNAG SDEDCVLLLK NGQWNDVPCS TSHLAVCEFP I