Recombinant humaan MK6 eiwit

MAP2K6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, MAP2K6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Recombinant human MAP2K6, fused to His-tag at N-terminus, was expressed in E. coli.

Mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase kinase 6, MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.25 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

32.0 kDa (383aa)

MKK6, Mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase kinase 6, MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3, ATGP2942-10 µg, ATGP2942-20 µg, ATGP2942-50 µg, ATGP2942-100 µg, ATGP2942-250 µg, ATGP2942-500 µg, ATGP2942-1 mg, ATGP2942-10, ATGP2942-20, ATGP2942-50, ATGP2942-100, ATGP2942-250, ATGP2942-500, ATGP2942-1

Manning G., et al. (2002) Science 298 (5600) : 1912-34; ; Pearson G., et al. (2002) Endocr. Rev. 22 (2) : 153-83;

Kim DO, et al. TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection. (Int J Mol Sci. 2020) {https://pubmed.ncbi.nlm.nih.gov/33327533/}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Cell Cycle

NP_002749

P52564

Human

MLEPIMELGR GAYGVVEKMR HVPSGQIMAV KRIRATVNSQ EQKRLLMDLD ISMRTVDCPF TVTFYGALFR EGDVWICMEL MDTSLDKFYK QVIDKGQTIP EDILGKIAVS IVKALEHLHS KLSVIHRDVK PSNVLINALG QVKMCDFGIS GYLVDEVAKE IDAGCKPYMA PERINPELNQ KGYSVKSDIW SLGITMIELA ILRFPYDSWG TPFQQLKQVV EEPSPQLPAD KFSAEFVDFT SQCLKKNSKE RPTYPELMQH PFF