Recombinant humaan MRGBP-eiwit

MRG-binding protein, also known as MRGBP, is a 204 amino acid protein which is a part of the NuA4 histone acetyltransferase (HAT) complex that acts to acetylate histone H2A and H4. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. MRGBP has potential to interact with MORF4L1/MRG15 and MORF4L2/MRGX. Recombinant human MRGBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

MRG-binding protein, MRG15BP, uRCC4, C20orf20

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

24.5 kDa (224aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

MRGBP, MRG-binding protein, MRG15BP, uRCC4, C20orf20, ATGP1315-10 µg, ATGP1315-20 µg, ATGP1315-50 µg, ATGP1315-100 µg, ATGP1315-250 µg, ATGP1315-500 µg, ATGP1315-1 mg, ATGP1315-10, ATGP1315-20, ATGP1315-50, ATGP1315-100, ATGP1315-250, ATGP1315-500, ATGP1315-1

Doyon Y., et al. (2004) Mol Cell Biol. 24:1884-1896.; ; Squatrito M., et al. (2006) Trends Cell Biol. 16:433-442.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.2M NaCl

Epigenomics (Transcription & Translation)

NP_060740

Q9NV56

Human

MGEAEVGGGG AAGDKGPGEA ATSPAEETVV WSPEVEVCLF HAMLGHKPVG VNRHFHMICI RDKFSQNIGR QVPSKVIWDH LSTMYDMQAL HESEILPFPN PERNFVLPEE IIQEVREGKV MIEEEMKEEM KEDVDPHNGA DDVFSSSGSL GKASEKSSKD KEKNSSDLGC KEGADKRKRS RVTDKVLTAN SNPSSPSAAK RRRT