Recombinant humaan MST2/STK3-eiwit

STK3, also known as serine/threonine-protein kinase 3, is a mammalian Ste20-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. It is a serine/threonine kinase that functions early in a pheromone responsive signal transduction cascade in yeast. It activates the human large tumor suppressor kinase Lats1. It modulates stress-induced cardiac hypertrophy. Recombinant human STK3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Serine/threonine-protein kinase 3, STK3, KRS1, MST2

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

37.6 kDa (331aa)

MST2, STK3, Serine/threonine-protein kinase 3, STK3, KRS1, MST2, ATGP3452-10 µg, ATGP3452-20 µg, ATGP3452-50 µg, ATGP3452-100 µg, ATGP3452-250 µg, ATGP3452-500 µg, ATGP3452-1 mg, ATGP3452-10, ATGP3452-20, ATGP3452-50, ATGP3452-100, ATGP3452-250, ATGP3452-500, ATGP3452-1

Chan EH., et al. (2005) Oncogene. 24:2076-2086.; ; Taylor LK., et al. (1996) Proc Natl Acad Sci U S A. 93:10099-10104.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Apoptosis

NP_006272

Q13188

Human

Ala

MEQPPAP KSKLKKLSED SLTKQPEEVF DVLEKLGEGS YGSVFKAIHK ESGQVVAIKQ VPVESDLQEI IKEISIMQQC DSPYVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT LIEDEIATIL KSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITSIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW SDDFTDFVKK CLVKNPEQRA TATQLLQHPF IKNAKPVSIL RDLITEAMEI KAKRHEEQQR ELEEEEENSD EDELD