Recombinant humaan MTPN-eiwit

MTPN (myotrophin), an ankyrin repeat protein, is stimulates protein synthesis and cardiomyocyte growth to initiate cardiac hypertrophy by activating the NF-kappaB signaling cascade. This protein plays a potential role in cerebellar morphogenesis and may function in differentiation of cerebellar neurons, particularly of granule cells. Elevated levels of MTPN are expressed in human dilated cardiomyopathic and ischemic hearts. Recombinant human MTPN, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Myotrophin, Protein V-1, GCDP, Myotrophin, Protein V 1, Protein V1

E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

15 kDa (138aa) confirmed by MALDI-TOF

MTPN, Myotrophin, Protein V-1, GCDP, Myotrophin, Protein V 1, Protein V1, ATGP0621-10 µg, ATGP0621-20 µg, ATGP0621-50 µg, ATGP0621-100 µg, ATGP0621-250 µg, ATGP0621-500 µg, ATGP0621-1 mg, ATGP0621-10, ATGP0621-20, ATGP0621-50, ATGP0621-100, ATGP0621-250, ATGP0621-500, ATGP0621-1

Sen S., et al. (2008) J Biol Chem. 283 (41) :27947-56.; ; Sivasubramanian N., et al (2002) J Biol Chem. 277 (26) :23888-97.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Neuroscience

NP_665807

P58546

Human

MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPDGLTAFEATDN QAIKALLQ