Recombinant humaan MyD88-eiwit

Myeloid differentiation primary response gene 88, also known as MYD88, acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein increases IL-8 transcription. It is involved in IL-18-mediated signaling pathway. MYD88 activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Recombinant human MYD88 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Myeloid differentiation primary response protein MyD88, MYD88D

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.5 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

38.7 kDa (345aa)

MyD88, ATGP1894-10 µg, ATGP1894-20 µg, ATGP1894-50 µg, ATGP1894-100 µg, ATGP1894-250 µg, ATGP1894-500 µg, ATGP1894-1 mg, ATGP1894-10, ATGP1894-20, ATGP1894-50, ATGP1894-100, ATGP1894-250, ATGP1894-500, ATGP1894-1

Kawai T., et al. (2004) Nat. Immunol A. 5:1061-1068; ; Semaan N., et al. (2008) J. Immunol. 180:3485-3491

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Signal Transduction

NP_002459.2

Q99836

Human

MRPD RAEAPGPPAM AAGGPGAGSA APVSSTSSLP LAALNMRVRR RLSLFLNVRT QVAADWTALA EEMDFEYLEI RQLETQADPT GRLLDAWQGR PGASVGRLLE LLTKLGRDDV LLELGPSIEE DCQKYILKQQ QEEAEKPLQV AAVDSSVPRT AELAGITTLD DPLGHMPERF DAFICYCPSD IQFVQEMIRQ LEQTNYRLKL CVSDRDVLPG TCVWSIASEL IEKRCRRMVV VVSDDYLQSK ECDFQTKFAL SLSPGAHQKR LIPIKYKAMK KEFPSILRFI TVCDYTNPCT KSWFWTRLAK ALSLP