Recombinant humaan NDRG1-eiwit

N-myc downstream regulated gene (NDRG) -1 is one of 4 members of the NDRG alpha/beta-hydrolase family. This protein is classified in databases as a tumor suppressor and heavy metal-response protein. Its functions include cell-cycle regulation, cellular differentiation, apoptosis, hypoxia response and metal-ion sensing. Mutation in the NDRG1 gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom (HMSNL), a severe autosomal recessive form of Charcot-Marie-Tooth (CMT) disease. Recombinant human NDRG1, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography.

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E.coli

Human

His-Tag

SDS-PAGE

1 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

43.9 kDa (402aa) confirmed by MALDI-TOF

NDRG1, ATGP0386-10 µg, ATGP0386-20 µg, ATGP0386-50 µg, ATGP0386-100 µg, ATGP0386-250 µg, ATGP0386-500 µg, ATGP0386-1 mg, ATGP0386-10, ATGP0386-20, ATGP0386-50, ATGP0386-100, ATGP0386-250, ATGP0386-500, ATGP0386-1

Richardson DR., et al. (2008) Biochim Biophys Acta. 1783 (10) :1981-92.; ; Costa M., et al. (2008) Carcinogenesis. 29 (1) :2-8.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1mM PMSF, 10% glycerol

Cancer

NP_006087

Q92597

Human