Recombinant humaan Nectine-2/CD112 eiwit

NECTIN2, also known as nectin-2 isoform delta, is a Ca (2+) -independent cell-cell adhesion molecule that is one of the plasma membrane components of adherens junctions. It is a key player for the establishment of homotypic and heterotypic cell to cell contacts. It is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells. It is a potential target for antibody therapy of breast and ovarian cancers. It might be associated with human longevity. Recombinant human NECTIN2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Nectin-2 isoform delta, NECTIN2, CD112, HVEB, PRR2, PVRL2, PVRR2

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

36.3 kDa (337aa)

Nectin2, CD112, Nectin-2 isoform delta, NECTIN2, CD112, HVEB, PRR2, PVRL2, PVRR2, ATGP3641-10 µg, ATGP3641-20 µg, ATGP3641-50 µg, ATGP3641-100 µg, ATGP3641-250 µg, ATGP3641-500 µg, ATGP3641-1 mg, ATGP3641-10, ATGP3641-20, ATGP3641-50, ATGP3641-100, ATGP3641-250, ATGP3641-500, ATGP3641-1

Devilard E., et al. (2013) PLoS One. 8:e77424.; ; Oshima T., et al. (2013) Mol Cancer. 12:60.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001036189

Q92692

Human

Gln32

QDVRVQVLPE VRGQLGGTVE LPCHLLPPVP GLYISLVTWQ RPDAPANHQN VAAFHPKMGP SFPSPKPGSE RLSFVSAKQS TGQDTEAELQ DATLALHGLT VEDEGNYTCE FATFPKGSVR GMTWLRVIAK PKNQAEAQKV TFSQDPTTVA LCISKEGRPP ARISWLSSLD WEAKETQVSG TLAGTVTVTS RFTLVPSGRA DGVTVTCKVE HESFEEPALI PVTLSVRYPP EVSISGYDDN WYLGRTDATL SCDVRSNPEP TGYDWSTTSG TFPTSAVAQG SQLVIHAVDS LFNTTFVCTV TNAVGMGRAE QVIFVRETPN TAGAGATGGL EHHHHHH