Recombinant humaan Neurexophiline-1/NXPH1-eiwit

NXPH1, also known as Neurexophilin-1, is one of at least four vertebrate neuropeptide-like secreted glycoproteins in the neurexophilin family. It encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. Genetic deletion of NXPH1 and/or NXPH-3 produces no anatomical effect, although mice lacking NXPH-3 show defects in motor coordination. Recombinant human NXPH1 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Neurexophilin-1, NXPH1, Nbla00697, NPH1

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

29.7 kDa (259aa)

Neurexophilin1, NXPH1, Neurexophilin-1, NXPH1, Nbla00697, NPH1, ATGP3559-10 µg, ATGP3559-20 µg, ATGP3559-50 µg, ATGP3559-100 µg, ATGP3559-250 µg, ATGP3559-500 µg, ATGP3559-1 mg, ATGP3559-10, ATGP3559-20, ATGP3559-50, ATGP3559-100, ATGP3559-250, ATGP3559-500, ATGP3559-1

Kinzfogl J., et al. (2011) Blood. 118:565-575.; ; Wouters MM., et al. (2014) Gut. 63:1103-1111.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_689958

P58417

Human

Ala

ADPANLTNGG KSELLKSGSS KSTLKHIWTE SSKDLSISRL LSQTFRGKEN DTDLDLRYDT PEPYSEQDLW DWLRNSTDLQ EPRPRAKRRP IVKTGKFKKM FGWGDFHSNI KTVKLNLLIT GKIVDHGNGT FSVYFRHNST GQGNVSVSLV PPTKIVEFDL AQQTVIDAKD SKSFNCRIEY EKVDKATKNT LCNYDPSKTC YQEQTQSHVS WLCSKPFKVI CIYISFYSTD YKLVQKVCPD YNYHSDTPYF PSGHHHHHH