Recombinant humaan Neurokinine B-eiwit

Neurokinin B, a member of the substance P-related tachykinin family, was previously known to be present in the same hypothalamic neurons as kisspeptin. This protein and its receptor are critical switches of regulator of human puberty, governed by the brain through the release of the hormone GnRH (gonadotropin-releasing hormone) which starts a series of processes that ultimately leads to the production of sex hormones. Many studies suggest new approaches to the pharmacological control of human reproduction and sex hormone-related diseases. Recombinant human Neurokinin B, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

ZNEuROK1, Neuromedin K, Tachykinin3, TAC3, NKB, NKNB, Gamma tachykinin 3, Neurokinin B like protein, Neurokinin B protein, Neurokinin beta, NeurokininB, NeuromedinK, Preprotachykinin B, PreprotachykininB, PRO 1155, PRO1155, TAC 3, Tachykinin 3, Tachykinin3, ZNEuROK 1.

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 95% by SDS-PAGE

13.8 kDa (125aa) confirmed by MALDI-TOF

Neurokinin B, ATGP0362-10 µg, ATGP0362-20 µg, ATGP0362-50 µg, ATGP0362-100 µg, ATGP0362-250 µg, ATGP0362-500 µg, ATGP0362-1 mg, ATGP0362-10, ATGP0362-20, ATGP0362-50, ATGP0362-100, ATGP0362-250, ATGP0362-500, ATGP0362-1

Topaloglu AK., et al. (2009) . Nat Genet. 41 (3) :354-8; ; Rance NE., et al. (2009) . Peptides. 30 (1) :111-22.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol

Neuroscience

NP_037383

Q9UHF0

Human

QSFGAVCKE PQEEVVPGGG RSKRDPDLYQ LLQRLFKSHS SLEGLLKALS QASTDPKEST SPEKRDMHDF FVGLMGKRSV QPDSPTDVNQ ENVPSFGILK YPPRAE