Recombinant humaan NOGO-receptor/RTN4R-eiwit

RTN4R, also known as reticulon-4 receptor, is a glycosylphosphoinositol (GPI) -anchored protein that belongs to the Nogo recptor family including three members. It is expressed predominantly in neurons and their axons in the central nervous systems (CNS) . It may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD) . It may play a role in regulating the function of the gap junctions. Recombinant human RTN4R, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Reticulon-4 receptor, RTN4R, NGR, NOGOR, Nogo-66 receptor

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

46.3 kDa (429aa)

Nogo Receptor, Reticulon-4 receptor, RTN4R, NGR, NOGOR, ATGP3443-10 µg, ATGP3443-20 µg, ATGP3443-50 µg, ATGP3443-100 µg, ATGP3443-250 µg, ATGP3443-500 µg, ATGP3443-1 mg, ATGP3443-10, ATGP3443-20, ATGP3443-50, ATGP3443-100, ATGP3443-250, ATGP3443-500, ATGP3443-1

Tong S., et al. (2013) Oncol Rep. 30:2171-2178.; ; Wang X., et al. (2012) Exp Neurol. 237:55-69.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_075380.1

Q9BZR6

Human

Cys27