Recombinant humaan NRG4-eiwit

NRG4 belongs to the neuregulin family and contains 1 EGF-like domain. The protein is low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Recombinant human NRG4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Pro-neuregulin-4 membrane-bound isoform, Pro-neuregulin-4, membrane-bound isoform, Neuregulin 4, HRG4

E.coli

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

9.1 kDa (84aa) confirmed by MALDI-TOF

NRG4, Pro-neuregulin-4 membrane-bound isoform, Pro-neuregulin-4, membrane-bound isoform, Neuregulin 4, HRG4, ATGP2472-10 µg, ATGP2472-20 µg, ATGP2472-50 µg, ATGP2472-100 µg, ATGP2472-250 µg, ATGP2472-500 µg, ATGP2472-1 mg, ATGP2472-10, ATGP2472-20, ATGP2472-50, ATGP2472-100, ATGP2472-250, ATGP2472-500, ATGP2472-1

Zody M.C., Garber M et al. (2006), Nature 440:671-675

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 0.15M NaCl, 1mM DTT

Signal Transduction

NP_612640

Q8WWG1

Human

MGSSHHHHHH SSGLVPRGSH MGSMPTDHEE PCGPSHKSFC LNGGLCYVIP TIPSPFCRCV ENYTGARCEE VFLPGSSIQT KSNL