Recombinant humaan OMgp-eiwit

OMG, also known as oligodendrocyte-myelin glycoprotein, is a cell membrane protein which contains eight leucine-rich repeats. This protein is expressed on the surface of oligodendrocytes and on large projection neurons, including Purkinje cells of the cerebellum, pyramidal cells of the hippocampus, motoneurons of the brainstem and anterior horn cells of the spinal cord. The neurite outgrowth inhibitory activities of all three myelin-derived proteins are mediated by binding to a common receptor complex consisting of the Nogo receptor and te p75 neurotrophin receptor. Recombinant human OMG, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Oligodendrocyte-myelin glycoprotein, OMG, OMGP, Oligodendrocyte-myelin glycoprotein, Omg, OMGP_HUMAN

Baculovirus

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

45.4 kDa (401aa)

OMgp, Oligodendrocyte-myelin glycoprotein, OMG, OMGP, Oligodendrocyte-myelin glycoprotein, Omg, OMGP_HUMAN, ATGP3414-10 µg, ATGP3414-20 µg, ATGP3414-50 µg, ATGP3414-100 µg, ATGP3414-250 µg, ATGP3414-500 µg, ATGP3414-1 mg, ATGP3414-10, ATGP3414-20, ATGP3414-50, ATGP3414-100, ATGP3414-250, ATGP3414-500, ATGP3414-1

Kottis V., et al. (2002) J Neurochem. 82:1566-1569.; ; Habib AA., et al. (1998) J Neurochem. 70:1704-1711.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Neuroscience

NP_002535.3

P23515

Human

Ile25