Recombinant humaan Oncstatine M/OSM-eiwit

OSM, also known as Oncostatin M, is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction. OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. Recombinant human OSM protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Oncostatin M, MGC20461, Oncostatin M precursor

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

< 1 EU per 1ug of protein (determined by LAL method)

> 95% by SDS-PAGE

25.9 kDa (230aa) confirmed by MALDI-TOF

Oncostatin M, OSM, Oncostatin M, MGC20461, Oncostatin M precursor, ATGP1123-10 µg, ATGP1123-20 µg, ATGP1123-50 µg, ATGP1123-100 µg, ATGP1123-250 µg, ATGP1123-500 µg, ATGP1123-1 mg, ATGP1123-10, ATGP1123-20, ATGP1123-50, ATGP1123-100, ATGP1123-250, ATGP1123-500, ATGP1123-1

Nair B.C., et al. (1992) Science. 255:1430-1432; ; Miles S.A., et al. (1992) Science. 255:1432-1434

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1mM DTT

Hormones & Cytokines

NP_065391

P13725

Human

AAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSE ETLRGLGRRG FLQTLNATLG CVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMA QLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRF LHGYHRFMHS VGRVFSKWGE SPNRSRRHSP HQALRKGVRR