Recombinant humaan OSCAR-eiwit

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. OSCAR is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Recombinant human OSCAR protein, fused to His-tag at N-terminus, was expressed in E. coli.

Osteoclast-associated immunoglobulin-like receptor isoform 1, PIGR3

E.coli

Human

His-Tag

SDS-PAGE, Denatured

0.25 mg/mL (determined by Bradford assay)

> 85% by SDS-PAGE

31.2 kDa (291aa)

OSCAR, Osteoclast-associated immunoglobulin-like receptor isoform 1, PIGR3, ATGP2129-10 µg, ATGP2129-20 µg, ATGP2129-50 µg, ATGP2129-100 µg, ATGP2129-250 µg, ATGP2129-500 µg, ATGP2129-1 mg, ATGP2129-10, ATGP2129-20, ATGP2129-50, ATGP2129-100, ATGP2129-250, ATGP2129-500, ATGP2129-1

Kim N, Takami M, et al. (2002) . J Exp Med. 195 (2) :201-9.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Osteoporosis

NP_996554.1

Q8IYS5

Human

DITPSVA IIVPPASYHP KPWLGAQPAT VVTPGVNVTL RCRAPQPAWR FGLFKPGEIA PLLFRDVSSE LAEFFLEEVT PAQGGIYRCC YRRPDWGPGV WSQPSDVLEL LVTEELPRPS LVALPGPVVG PGANVSLRCA GRLRNMSFVL YREGVAAPLQ YRHSAQPWAD FTLLGARAPG TYSCYYHTPS APYVLSQRSE VLVISWEGEG PEARPASSAP GMQAPGPPPS DPGAQAPSLS SFRPRGLVLQ PLLPQTQDSW DPAPPPSDPG V