Recombinant humaan OSCAR-eiwit

OSCAR, also known as osteoclast-associated immunoglobulin-like receptor isoform 6, is an activating receptor expressed by human myeloid cells. It is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes. It is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. Its expression is detected specifically in preosteoclasts or mature osteoclasts. It is upregulated on monocytes from rheumatoid arthritis (RA) patients with active disease, and these monocytes show an increased proosteoclastogenic potential. Recombinant human OSCAR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Osteoclast-associated immunoglobulin-like receptor isoform 6, OSCAR, PIgR-3, PIGR3

Baculovirus

Human

His-Tag

SDS-PAGE

0.25 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

29.2 kDa (270aa)

OSCAR, Osteoclast-associated immunoglobulin-like receptor isoform 6 , OSCAR, PIgR-3, PIGR3, ATGP3806-10 µg, ATGP3806-20 µg, ATGP3806-50 µg, ATGP3806-100 µg, ATGP3806-250 µg, ATGP3806-500 µg, ATGP3806-1 mg, ATGP3806-10, ATGP3806-20, ATGP3806-50, ATGP3806-100, ATGP3806-250, ATGP3806-500, ATGP3806-1

Schultz HS., et al. (2016) Eur J Immunol. 46:952-963.; ; Zhou L., et al. (2016) Blood. 127:529-537.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_001269278

Q8IYS5

Human

Asp19