Recombinant humaan OVCA2-eiwit

Ovarian tumor suppressor candidate 2, also known as OVCA2, belongs to the uPF0483 family. It is ubiquitously expressed and its expression is regulated by retinoids. OVCA2 interacts with apoptosis-related protein Bag-1, indicating that this protein may participate in cell proliferation. Due to its structural and catalytic characteristics, OVCA2 is thought to act as a serine-hydrolase and, because of its reduced expression in ovarian and other tumor cell lines, it may play a role in tumor suppression. Recombinant human OVCA2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Ovarian tumor suppressor candidate 2, Ovarian cancer-associated gene 2 protein

E.coli

Human

His-Tag

SDS-PAGE

0.5 mg/mL (determined by Bradford assay)

> 90% by SDS-PAGE

26.9 kDa (251aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

OVCA2, Ovarian tumor suppressor candidate 2, Ovarian cancer-associated gene 2 protein, ATGP1618-10 µg, ATGP1618-20 µg, ATGP1618-50 µg, ATGP1618-100 µg, ATGP1618-250 µg, ATGP1618-500 µg, ATGP1618-1 mg, ATGP1618-10, ATGP1618-20, ATGP1618-50, ATGP1618-100, ATGP1618-250, ATGP1618-500, ATGP1618-1

Azizi A A., et al. (2006) Cancer Lett. 241 (2) :235-49.; ; Prowse A H., et al. (2002) Int J Cancer. 99 (2) : 185-92.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT

Cancer

NP_543012

Q8WZ82

Human

MGSSHHHHHH SSGLVPRGSH MGSHMAAQRP LRVLCLAGFR QSERGFREKT GALRKALRGR AELVCLSGPH PVPDPPGPEG ARSDFGSCPP EEQPRGWWFS EQEADVFSAL EEPAVCRGLE ESLGMVAQAL NRLGPFDGLL GFSQGAALAA LVCALGQAGD PRFPLPRFIL LVSGFCPRGI GFKESILQRP LSLPSLHVFG DTDKVIPSQE SVQLASQFPG AITLTHSGGH FIPAAAPQRQ AYLKFLDQFA E