Recombinant humaan OX40/TNFRSF4-eiwit

TNFRSF4, also known as tumor necrosis factor receptor superfamily member 4, is a T cell co-stimulatory molecule in the TNF receptor superfamily. This protein coordinates with other co-stimulatory substances (CD28, CD40, CD30, CD27 and 4-1BB) to control the activation of the immune response. It plays an important role in antigen-specific T cell expansion and survival. It is up-regulated on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. This protein also regulates cytokine production from T cells, antigen presenting cells, natural killer cells and natural killer cells and regulate cytokine receptor signaling. Recombinant human TNFRSF4, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Tumor necrosis factor receptor superfamily member 4, TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor

Baculovirus

Human

HIgG-His-Tag

SDS-PAGE

0.5 mg/mL (determined by absorbance at 280 nm)

< 1 EU per 1ug of protein (determined by LAL method)

> 90% by SDS-PAGE

46.9Da (425aa)

OX40, TNFRSF4, Tumor necrosis factor receptor superfamily member 4, TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L, ATGP3686-10 µg, ATGP3686-20 µg, ATGP3686-50 µg, ATGP3686-100 µg, ATGP3686-250 µg, ATGP3686-500 µg, ATGP3686-1 mg, ATGP3686-10, ATGP3686-20, ATGP3686-50, ATGP3686-100, ATGP3686-250, ATGP3686-500, ATGP3686-1

Hori, T., et al. (2006) Int. J. Hematol. 83:17-22.; ; Moran, A.E., et al. (2013) Curr. Opin. Immunol. 25:230-237.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

NP_003318

P43489

Human

Leu29